Shelf stable aspirin solutions

Details Shelf stable aspirin solutions Shelf stable aspirin solutions

1989-07-31

1990-12-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

514165, 514617, 514970, A61L 904, A61K 3160, A61K 31165

Patent

active

049752693

ABSTRACT:
There is provided a shelf stable solution of aspirin, free of moieties reactive with aspirin, suitable for topical application to the skin compounded from aspirin, N,N-diethyl-m-toluamide USP (DEET), glyceryltriacetate USP (GTA), and acetic anhydride, provided that where GTA is present, at least 20 parts of DEET shall also be present and, after all components shall have been mixed, the resultant solution shall contain an initial amount of between about 1 and about 0.2 parts of acetic anhydride. The solution is made by preparing a solvent component consisting of at least N,N-diethyl-m-toluamide USP (DEET), and, if desired, glyceryltriacetate USP (GTA), provided that where GTA is present, at least 20 parts of DEET shall also be present, assaying said solvent mixture to determine the hydroxyl content, adding sufficient acetic anhydride to provide between about 1 and about 0.2 parts of unreacted acetic anhydride in the solution after dissolution of the aspirin therein, and dissolving aspirin, thereinto.

REFERENCES:
patent: 4440777 (1984-04-01), Zupan
patent: 4560553 (1985-12-01), Zupan
patent: 4859696 (1989-08-01), Kamiya et al.

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