Stabilized interface for iontophoresis

Details Stabilized interface for iontophoresis Stabilized interface for iontophoresis

1996-03-12

1998-11-17

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, 428245, 428260, 428262, 428289, 4283044, 604304, 604305, A61K 970, A61M 3700, B32B 300

Patent

active

058372814

ABSTRACT:
An interface is formed by incorporating (1) a mixture comprising a water-soluble protein and a drug into a matrix, or preferably (2) a mixture comprising a water-soluble protein and a drug to a porous matrix coated with a cationic surfactant or other ionic surfactant. The coating amount of the ionic surfactant is about 0.1 to 50 .mu.g, and the content of the water-soluble protein is about 0.1 to 1,500 .mu.g, each per 1 cm.sup.2 of the matrix. The water-soluble protein includes an albumin and the drug includes a physiologically active peptide or protein, for example. The use of the stabilized interface inhibits decrease of the drug retaining amount, and insures an effective transdermal drug delivery with a high repeatability and accuracy.

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Patent Abstracts of Japan, vol. 018, No. 222 (C-1193) of JP-A-06 016535.

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