Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1996-01-19
1998-11-17
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 60, 514167, A61K 742, A61K 3159
Patent
active
058372245
ABSTRACT:
Photoaging of undamaged skin due to UVB irradiation exposure is inhibited by administering an agent that inhibits (1) the activity of UVB irradiation inducible MMPs in the skin, (2) one or both of the transcription factors AP-1 and NF-.kappa.B or (3) at least one of the GTP binding proteins or kinases involved in the activation and/or production of jun or fos proteins, which comprise AP-1, to the skin prior to such exposure.
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Fisher Gary J.
Voorhees John J.
Dodson Shelley A.
The Regents of the University of Michigan
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