Thioproline-containing inhibitors of farnesyl protein transferas

Details Thioproline-containing inhibitors of farnesyl protein transferas Thioproline-containing inhibitors of farnesyl protein transferas

1997-10-17

1999-07-27

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142278, 5142358, 514248, 514249, 514252, 540524, 540598, 544 581, 544 60, 544121, 544235, 544238, 544283, 544335, 544353, 544357, 544360, 544364, 544365, 544372, 544386, 544387, 544388, A61K 31495, C07D40302, C07D24102

Patent

active

059290773

ABSTRACT:
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected b ##STR1## its enantiomers, diastereomers, and pharmaceutically acceptable salts and solvates thereof.

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