Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-06-03
1999-07-27
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 5361231, 53612313, 536124, A61K 3170, A61K 31715, C07H 108, C07H 304
Patent
active
059290471
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to an anti-viral agent comprising acidic polysaccharides having an antioxidant activity and a free radical (reactive oxygen species)-scavenging activity extracted as an active component from pecan nut, pine cone Eucommia plant(bark), Eucommia tea(leaf and twigs) Aspalathus linearis belonging to the Leguminosae family, mangroves, and Momordica charantia, and which are effective against retroviruses such as human immuno deficiency virus (HIV), with no side-effects on human and/or animals, easy to ingest daily and have preventive activity against virus infection, and also relates to a process of manufacturing the same.
BACK GROUND OF THE INVENTION
Numerous anti-viral agents are known heretofore.
However, most of the anti-viral agents developed so far are costly, and have weak efficacy and usually have side-effects which might have been severe and serious.
There are many diseases caused by viruses such as influenza, hepatitis, measles, Japanese encephalitis, human T-cell leukemia, and AIDS, and unfortunately though there are few effective chemotherapy treatments which show a definite effectiveness against these kinds of viral diseases, and in particular there is no medicine which is sufficiently effective against retroviruses which cause human T-cell leukemia or AIDS, without side-effects. Moreover, there are no anti-viral agents known which can be ingestable daily like food and drink and have preventative effects with no side-effects.
Recently a hot water extract of Aspalathus linearis is recognized effective against virus but the reason for its effectiveness is still unknown and research for searching for a stronger anti virus agent has been continued.
The purpose of the present invention is to resolve the above mentioned problems and to provide an anti-viral agent having an anti-oxidant activity and free radical-scavenging activity which is effective against retroviruses and has a protective activity without side-effects; and to provide a process of manufacturing such anti-viral agent.
DESCRIPTION OF THE INVENTION
The inventors of this application undertook an extensive research in order to resolve the above mentioned problems and discovered that acidic polysaccharides obtained from mangrove, Momordica charantia L., and Aspalathus linearis, have a strong anti-viral activity, an anti-oxidant activity and a free radical-scavenging activity, and they have no side-effects and are safe on human and/or animals, and thus the present invention was developed.
Acidic polysaccharides stated above can be obtained by an alkaline extract method of mangrove, Momordica charantia L., and Aspalathus linearis, which contain an uronic acid, neutral sugars and reducing sugars.
And further by hydrolyzing the acidic polysaccharides obtained from the plants in an acid, an anti-viral agent containing disaccharides and trisaccharides is produced.
THE BEST MODE OF THE INVENTION
Preferable plants for extraction are mangrove, Momordica charantia L., and Aspalathus linearis belonging to the Leguminosae family, etc.
A further research on acidic polysaccharides obtained from plants shows that the polysaccharides containing uronic acids, neutral sugars and reducing sugars have a very strong antioxidant activity and a free radical scavenging activity and an anti viral effects. The acidic polysaccharides having these features are obtained by an alkaline hot water extraction method.
The effective ingredients of this invention is obtained by extracting the respective plants in hot water, such as mangrove, Momordica charantia L., and Aspalathus linearis belonging to the Leguminosae family, etc. and then by adding an alkaline solution to the residues from the first hot water extraction, the alkaline extracts are obtained. Also the effective components can be obtained without extracting the plants in hot water but only by extracting the plants in the alkaline solution directly.
In the hot water extraction process, the amount of water may be 10 to 100 times of the weight of Aspalathus
REFERENCES:
patent: 4985249 (1991-01-01), Sakagami et al.
Patent Abstracts of Japan of JP 05-271061 published Oct. 19, 1993.
Patent Abstracts of Japan of JP 05-271062 published Oct. 19, 1993.
Patent Abstracts of Japan of JP 05-271090 published Oct. 19, 1993.
Patent Abstracts of Japan of JP 05-286866 published Nov. 2, 1993.
Patent Abstracts of Japan of JP 06-128121 published May 10, 1994.
Patent Abstracts of Japan of JP 06-199696 published Jul. 19, 1994.
Patent Abstracts of Japan of JP 06-199697 published Jul. 19, 1994.
Patent Abstracts of Japan of JP 07-039339 published Feb. 10, 1995.
Patent Abstracts of Japan of JP 08-151329 published Jun. 11, 1996.
Patent Abstracts of Japan, vol. 95, No. 5, Jun. 30, 1995 of JP 07 039339 A (Nippon Ruibosuteii Honsha KK), Feb. 10, 1995.
Patent Abstracts of Japan, vol. 18, No. 46 (C-1157), Jan. 25, 1994 of JP 05 271062 A (Ruibosuteii Japan KK et al), Oct. 19, 1993.
Patent Abstracts of Japan, vol. 18, No. 46 (C-1157), Jan. 25, 1994 of JP 05 271063 A(Ruibosuteii Japan KK et al) Oct. 19, 1993.
M. Premnathan et al, "A Survey of Some Indian Marine Plants for Antiviral Activity", Botanica Marina, vol. 35, 1992, pp. 321-324.
K. Komatsu et al, "Inhibitory effects of Rooibos tea, Aspalathus linealis , on X-ray-induced C3H10T1/2 cell transformation", Cancer Letters vol. 77, 1994, pp. 33-38.
D. Takemoto et al, "Purification and characterization of a cytostatic factor with anti-viral activity from the bitter melon", Preparative Biochemistry, vol. 13, No. 4, 1983, pp. 371-393.
Kunz Gary L.
Mitsui Norin Co., Ltd.
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