Extracellular mucous matrix glycoprotein

Details Extracellular mucous matrix glycoprotein Extracellular mucous matrix glycoprotein

1998-02-10

1999-07-27

Lau, Kawai

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 6, 435 691, 4352523, 4353201, 514 44, 530350, 536 232, A61K 3817, C12Q 168, C12P 2102, C07H 2104

Patent

active

059290331

ABSTRACT:
The invention provides a human extracellular mucous matrix glycoprotein (EMMG) and polynucleotides which identify and encode EMMG. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of EMMG.

REFERENCES:
Database EMBL/GenBank, Accession No. W53028, Hillier, L. et al., Sep. 1996.
Database EMBL/Genbank, Accession No. AA295047, Adams M.D. et al. "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." Nature (Sep. 1995), vol. 377, No. 6547S, pp. 3-174.
Anholt, R.R.H. et al. "Identification of olfactomedin as a unique variant of histomedin, a highly conserved protein expressed in rat, human and Drosophila." Chemical Senses, Sixteenth Annual Meeting of the Association for Chemoreception Sciences, (Apr. 1994).
Mazanec, M.B. et al., "A three-tierd view of the role of IgA in mucosal defense", Immunol. Today, 14: 430-435 (1993).
Takagi, S.F., Human Olfaction, University of Tokyo Press, Tokyo, Japan (1989).
Snyder, D.A. et al., "Olfactomedin: Purification, Characterization, and Localization of a Novel Olfactory Glycoprotein", Biochemistry, 30: 9143-9153 (1991).
Yokoe, H. and R.H. Anholt, "Molecular cloning of olfactomedin, and extracellular matrix protein specific to olfactory neuroepithelium", Proc. Natl. Acad. Sci. USA, 90: 4655-4659 (1993).
Yokoe, J. and R.H. Anholt, (Direct Submission), GenBank Sequence Database (Accession 294502), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 294502), 1993.
Yokoe, J. and R.H. Anholt, (Direct Submission), GenBank Sequence Database (Accession L13595), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 294501, GI 294502), 1993.

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