Repressor kruppel-like factor

Details Repressor kruppel-like factor Repressor kruppel-like factor

1997-10-07

1999-07-27

McKelvey, Terry

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435243, 4353201, 435410, 536 235, C12N 100, C12N 510, C12N 1512, C12N 1563

Patent

active

059289414

ABSTRACT:
Disclosed is a novel mammalian protein designated repressor Kruppel-like factor (RKLF). RKLF is a zinc finger protein that binds to a CACCC element in DNA, thereby repressing gene transcription. An isolated DNA encoding RKLF, vectors and cells containing the DNA, and RKLF-specific antibodies are also disclosed. The RKLF DNA or protein can be introduced into the tissues of a mammal to inhibit neoplasia or hyperplasia. Also disclosed is an in vitro screening method for identifying a compound that induces RKLF gene expression.

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