Human geranylgeranyl pyrophosphate synthetase

Details Human geranylgeranyl pyrophosphate synthetase Human geranylgeranyl pyrophosphate synthetase

1998-03-11

1999-07-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 4352523, 4353201, 536 232, 536 2431, C12N 910, C12N 1554, C12N 1563, C12N 1579

Patent

active

059289244

ABSTRACT:
A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.

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