Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1998-02-05
1999-07-27
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435 6, 435 912, 4353201, 43525233, 514 44, 530350, 536232, C07K 2104, C12N 510, C12N 902, C12N 1552
Patent
active
059289236
ABSTRACT:
The invention provides a human short-chain dehydrogenase (HSCD) and polynucleotides which identify and encode HSCD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HSCD.
REFERENCES:
Strausberg, R., GenBank Accession No. AA283169, Apr. 5, 1997.
Ghosh, D, et al., Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 angstrom resolution. Structure 3:503-513, May 15, 1995.
Duax, W.L. and Ghosh, D. Structure and function of steroid dehydrogenases involved in hypertension, fertility, and cancer. Steroids. 62:95-100, 1997.
Naeve, C.W., et al., Accuracy of automated DNA sequencing: a multilaboratory comparison of sequencing results. Biotechniques 19(3):448-453, 1995.
Corydon, M.J. et al., "Structural organization of the human short-chain acyl-CoA dehydrogenase gene", Mamm. Genome, 8: 922-926 (1997).
Wilson, R. et al., (Direct Submission), GenBank Sequence Database (Accession 2315796), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 235796) Aug. 1, 1997.
Wilson, R. et al., (Direct Submission), GenBank Sequence Database (Accession AF016685), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 2315795) Aug. 6, 1997.
Adamski, J. et al., "Purification and properties of oestradiol 17.beta.-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells", Biochem. J., 288: 375-381 (1992).
Corley Neil C.
Lal Preeti
Chan Christina Y.
Incyte Pharmaceuticals Inc.
Price Leanne C.
Tung Mary Beth
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