Threonyl tRNA synthetase from Staphylococcus aureus

Details Threonyl tRNA synthetase from Staphylococcus aureus Threonyl tRNA synthetase from Staphylococcus aureus

1997-12-23

1999-07-27

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435440, 435 6, 536 232, 536 243, 5303871, C12N 900, C12N 1500, C12Q 168, C07H 2104

Patent

active

059289201

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
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Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Putzer, et al., "Independent Genes for Two Threonyl-tRNA Synthetases in Bacillus subtilis", Journal of Bacteriology, 172, 8, pp. 4593-4602 (1990).
Fleischmann, et. al., "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd", Science, 269, No. 5223, pp. 496-512 (1995).
Ogasawara, et. al., "Nucleotide sequence and organization of dnaB gene and neighbouring genes on the Bacillus subtilis chromosome", Nucleic Acid Research 14, No. 24 pp. 9989-9999 (1986).
Putzer, et. al., "B subtilits threonyl tRNA synthetase (thrS) gene, complete cds.", EMBL Database, Entry BSTRNASB, Accession No. M36594, (Version 8), (1992).

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