Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1999-07-27
Saunders, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 435325, 435365, 536 235, C12N 1512
Patent
active
059288906
ABSTRACT:
A Human amine receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting compounds which bind to and activate and bind to and inhibit such polypeptide and the use of compounds for treating diseases related to the under-expression and over-expression of the Human amine receptor of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
REFERENCES:
Bunzow, J.R. et al., "Cloning and expression of a rat D.sub.2 dopamine receptor cDNA," Nature 336:783-787 (1988).
Eva, C. et al., "Molecular cloning of a novel G protein-coupled that may belong to the neuropeptide receptor family," FEBS Letts. 271(1.2):81-84 (1990).
Hla, T. and T. Maciag, "An Abundant Transcript Induced in Differentiating Human Endothelial Cells Encodes a Polypeptide with Structural Similarities to G-protein-coupled Receptors," J. Biol. Chem. 265(16):9308-9313 (1990).
Johnson, G.L. and N. Dhanasekaran, "The G-Protein Family and Their Interaction with Receptors," Endocrine Rev. 10(3):317-331 (1989).
Kobilka, B.K. et al., "cDNA for the human .beta..sub.2 -adrenergic receptor: A protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor," Proc. Natl. Acad. Sci. USA 84:46-50 (1987).
Kobilka, B.K. et al., "Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet .alpha..sub.2 -Adrenergic Receptor," Science 238:650-656 (1987).
Lefkowitz, R.J., "Thrombin Receptor: Variations on a theme," Nature 351:353-354 (1991).
Libert, F. et al., "Selective Amplification and Cloning of Four New Members on the G Protein-Coupled Receptor Family," Science 244:569-572 (1989).
Meyerhoff, W. et al., "Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermatogenesis," FEBS Letts. 284(2):155-160 (1991).
Ross, P.C. et al., "RTA, a candidate G protein-coupled receptor: Cloning, sequencing, and tissue distribution," Proc. Natl. Acad. Sci. USA 87:3052-3056 (1990).
Simon, M.I. et al., "Diversity of G Proteins in Signal Transduction," Science 252:802-808 (1991).
International Search Report for Application No. PCT/US95/07221.
Human Genome Sciences Inc.
Saunders David
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