Peptide derivatives and antidemetia agents

Details Peptide derivatives and antidemetia agents Peptide derivatives and antidemetia agents

1989-08-14

1994-05-17

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 530317, 530329, 530330, A61K 3702, C07K 510, C07K 706

Patent

active

053128117

ABSTRACT:
A novel peptide derivative having the formula: ##STR1## wherein A between Pro and Q.sup.2 is Arg or Lys: Q.sup.1 is pGlu or H; Q.sup.2 is --Gly--OH or OH; Y.sup.1 is H or --CO--T and Y.sup.2 is OH or T; wherein T is a thiamine derivative group is disclosed. The peptide derivative shows a remarkable nootropic effect.

REFERENCES:
Yasuo, H. "Synthesis and Properties of S-Aminomethylthiamine and N-Hydroxmethylthiamine", Chem. Pharm. Bull. 24(5) pp. 845-849, (1976).
Kovacs, et al, A Major Metabolite of Arginine Vasopressin in the Brain is a Highly Potent Neuropeptide, Science, 221, pp. 1310-1312 (1983).
Yasuo et al, "The reaction of S-aminomethylthiamine with Acid Anhydride-The synthesis of O,S-bis(.alpha.-aminoacyl) thiamine", Chem. Pharm. Bull. 1976, 24(5) 852-8 Chemical Abstracts, 85 (15) 108605v.

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