Fractionation of polyalkylene oxide-conjugated hemoglobin soluti

Details Fractionation of polyalkylene oxide-conjugated hemoglobin soluti Fractionation of polyalkylene oxide-conjugated hemoglobin soluti

1992-10-13

1994-05-17

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530385, 530344, A61K 3700, C07K 312

Patent

active

053128087

ABSTRACT:
Hemoglobin-containing solutions containing polyalkylene oxide-conjugated hemoglobin having a molecular weight greater than about 85,000 daltons and a degree of substitution of at least five polyalkylene oxide conjugates per hemoglobin molecule are described that are not associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is also disclosed.

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Shai et al. Biochemistry, (1989) 28 4801-4806.
"Hemoglobin," Van Nostrand's Scientific Encyclopedia (Seventh Ed., Considine, Ed., Van Nostrand Reinhold, New York, 1989) 1439-40.
Ajisaka et al., Biochem. Biophys. Res. Comm., 97(3), 1076-81 (1980).
Iwashita et al., Organ-Directed Toxic.: Chem. Indicies Mech., Proc. Symp. (Brown et al., Eds., Pergamon Oxford, England 1981), 97-101.
Iwasaki et al., Artf. Organs, 10(5), 411-6 (1986).
Abuchowski et al., Cancer Biochem. Biophys., 7, 175-86 (1984).

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