Process for debromination of dibromopenicillanic acid and deriva

Details Process for debromination of dibromopenicillanic acid and deriva Process for debromination of dibromopenicillanic acid and deriva

1983-06-06

1984-08-28

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424270, 424271, C07D49900, A61K 31425

Patent

active

044683510

ABSTRACT:
A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.

REFERENCES:
patent: 4180506 (1979-12-01), Pratt
patent: 4420426 (1983-12-01), Moore
patent: 4427678 (1984-01-01), Barth
patent: 4432970 (1984-02-01), Kellogg
Clayton, J. Chem. Soc. (C) pp. 2123-2127 (1969).

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