Synthesis of thiophene-containing prostaglandin endoperoxide ana

Details Synthesis of thiophene-containing prostaglandin endoperoxide ana Synthesis of thiophene-containing prostaglandin endoperoxide ana

1982-09-27

1985-05-28

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 22, 549 32, 549 60, 549 76, 549 77, 549 78, 544235, 546141, 546153, C07D33324

Patent

active

045202079

ABSTRACT:
New organopalladium reactions involving the addition of thienylpalladium compounds to strained bicyclic alkenes, and subsequent chain extension reactions employing the chemistry of organopalladium compounds are disclosed. By these techniques a large number of bicyclic prostaglandin analogs are prepared, which are useful as inhibitors of arachidonic acid induced blood platelet aggregation, and are specific inhibitors of thromboxane synthetase.

REFERENCES:
patent: 4351949 (1982-09-01), Larock

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