Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1984-05-25
1985-05-28
Roberts, Albert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26039745, 2603971, 2602395, C07J 5300
Patent
active
045199469
ABSTRACT:
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C=A group at position 3 is selected from the group consisting of C-O, ketal, which may be open or closed ##STR2## --C.dbd.NOH,--C--NOAlK.sub.3 and C--CH.sub.2,AlK.sub.1, AlK.sub.2 and AlK.sub.3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocoritcoid activity and a process for their preparation.
REFERENCES:
patent: 4386085 (1983-05-01), Teutsch et al.
Costerousse Germain
Deraedt Roger
Philibert Daniel
Teutsch Jean G.
Muserlian Charles A.
Roberts Albert L.
Roussel Uclaf
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