Method and kit for detecting human exposure to genotoxic agents

Details Method and kit for detecting human exposure to genotoxic agents Method and kit for detecting human exposure to genotoxic agents

1985-09-23

1988-12-27

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436501, 436517, 436536, 436813, 436815, 436822, C12Q 168, G01N 33536, G01N 33557

Patent

active

047940743

ABSTRACT:
The present invention discloses a method and a kit for monitoring human exposure to genotoxic agents. The method comprises an immunoassay for detecting in human serum specific antibodies against DNA adducted to an agent suspected of being genotoxic. A kit comprising various components for performing the assay is also disclosed.

REFERENCES:
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Poirier, M. C. Jour. Natl. Cancer Inst. 67: 515-519 (1981).
Heine, W. I. et al., Journ Amer. Med. Assoc. 182 No. 7: 726-729 (1962).
Dubroff, L. M. et al., Science 208:404-406 (1980).
Hsu et al., Cancer Research 41:1091-1095 (1981).
Shamsuddin et al., Cancer Research 45:66-68 (1985).
Harris et al., Proc. Natl. Acad. Sci. U.S.A., 82:6672-6676 (1985).

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