Bile acid derivatives and production thereof

Details Bile acid derivatives and production thereof Bile acid derivatives and production thereof

1987-01-28

1988-12-27

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 100

Patent

active

047939486

ABSTRACT:
A bile acid derivative having carcinostatic activity represented by the following formula (1): ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or a hydroxyl group, R.sub.3 is a hydroxyl group, benzyloxyl group or --NH--CH.sub.2n R.sub.5 (wherein R.sub.5 is a carboxyl group or sulfonyl group, and n represents the integer of 1 or 2), X is a halogen atom, R.sub.4 is a hydrogen atom or XCH.sub.2 CH.sub.2 --,.chi. is an .alpha.-bond, and .chi. is an .alpha.- or .beta.-bond is produced by the steps (a) and (b), the steps (a), (b) and (c), or the steps (a), (b), (c) and (d) described below:

REFERENCES:
Chemical Abstracts; vol. 103 (1985)#134470G; Baracu et al.
Chemical Abstracts; vol. 98 (1983)#179757A; Niculescu-Duvaz et al.
Chemical Abstracts; vol. 91 (1979)#211670K; Niculescu-Duvaz et al.
Chemical Abstracts; vol. 78 (1973)#136513N; Wolf et al.

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