Process for preparing pentafluoropentanol

Details Process for preparing pentafluoropentanol Process for preparing pentafluoropentanol

1998-09-18

1999-12-14

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 3134

Patent

active

060020539

ABSTRACT:
4,4,5,5,5-Pentafluoro-1-pentanol is prepared in a particularly advantageous manner from perfluoroethyl iodide by initially adding perfluoroethyl iodide in the presence of a radical initiator which does not carry any acyl groups to allyl alcohol and then hydrogenolytically dehalogenating the resulting 4,4,5,5,5-pentafluoro-2-iodo-1-pentanol in the presence of a catalyst, an acid binder and a diluent.

REFERENCES:
patent: 3145222 (1964-08-01), Brace
patent: 4073817 (1978-02-01), Jager
patent: 5254754 (1993-10-01), Amimoto
patent: 5502046 (1996-03-01), Bohlmann et al.
Kitazume, T and N Ishikawa. "Ultrasound-Promoted Selective Perfluoroalkylation on the Desired Position of Organic Molecules" J. Am. Chem. Soc. (1985) vol. 107, No. 18, pp. 5186-5191, published in US.
Larsson, U. "Synthesis of Amino Acids with Modified Principal Properties 1. Amino Acids with Fluorinated Side Chains" Acta Chemica Scandinavia (1993), vol. 47, pp. 380-390, published in Belgium.
Li, X et al., "Laboratory Scale Preparation of 4,4,5,5,5-Pentafluoropentan-1-thiol: An Important Chain of Anti-Breast Cancer Agents" Tetrahedron Letters (1994) vol. 35, No. 49, pp. 9141-9144, published in UK.
Park, JD et al. "Free-Radical Catalyzed Addition of Unsaturated Alcohols to Perhaloalkanes" J. Org. Chem. (Jun. 1961) vol. 26, pp. 2089-2095, published in US.

Affiliated with

Also associated with

Rating

Process for preparing pentafluoropentanol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing pentafluoropentanol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing pentafluoropentanol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-865191