Process for the production of prednisone 17.21-diacylates

Details Process for the production of prednisone 17.21-diacylates Process for the production of prednisone 17.21-diacylates

1985-01-28

1986-07-22

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603973, C07J 2100

Patent

active

046018549

ABSTRACT:
A novel process for the preparation of prednisone derivatives of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms and R.sub.2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 8 carbon atoms comprising reacting a compound of the formula ##STR2## with a reducing agent to obtain a compound of the formula ##STR3## reacting the latter with a strong base in the presence of copper ions and oxygen to obtain a compound of the formula ##STR4## reacting the latter with hydroxylamine to obtain a compound of the formula ##STR5## in its syn or anti isomeric form or a mixture thereof, reacting the latter with an acylating agent derived from a radical of the formula ##STR6## and with a reducing agent to obtain a compound of the formula ##STR7## in its Z or E isomeric form or a mixture thereof, subjecting the latter to treatment with an epoxidizing agent and then a dehydrating agent to obtain a compound of the formula ##STR8## reacting the latter with a halogenation agent and subjecting the resulting product to hydrolysis to obtain a compound of the formula ##STR9## wherein Hal is a halogen and reacting the latter with a derivative of an acyl of the formula R.sub.1 CO-- to obtain the compound of formula I which are known compounds.

REFERENCES:
patent: 4267106 (1981-05-01), Marx et al.
patent: 4328221 (1982-05-01), Farago et al.

Affiliated with

Also associated with

Rating

Process for the production of prednisone 17.21-diacylates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of prednisone 17.21-diacylates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of prednisone 17.21-diacylates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-865057