Oligonucleotides with non-standard bases and methods for prepari

Details Oligonucleotides with non-standard bases and methods for prepari Oligonucleotides with non-standard bases and methods for prepari

1995-01-17

1999-12-14

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2531, 536 2532, 536 2533, 536 2534, 536 254, 435 911, 435 9141, C07H 100, C07H 2100

Patent

active

060019832

ABSTRACT:
The disclosure describes new compositions of matter that are analogs of DNA and RNA containing heterocyclic bases that can form base pairs that fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but where these base pairs are joined by a pattern of hydrogen bonds different from that found in the AT and GC base pairs (a "non-standard base pair").

REFERENCES:
patent: 5126439 (1992-06-01), Rappaport
patent: 5432272 (1995-07-01), Benner
Golas, T., et al., Preparation and Properties of an Analogue of Poly(A) and Poly(G): Poly(isoguanylic acid), J. Biochem, 65:183-192, (1976).

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