Peptides which bind to anti-double stranded DNA antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence

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530324, 530325, 530326, 530327, 530328, 530329, 5303879, 5303871, C07K 706, C07K 708

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active

060019646

ABSTRACT:
The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compositions containing these peptides. The present invention also provides methods for the diagnosis and treatment of systemic lupus erythematosus utilizing the peptides of the present invention.

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Houghten et al, Nature, vol. 354, pp. 84-86, (Nov. 1991).
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Lory et al, J. Exp. Med., vol. 174, pp. 1639-1652, (Dec. 1991).
Yamada et al., J. Biochem., vol. 79, pp. 1223-1234 (1976).
Dokumov et al, British Journal of Obsterics and Gynaecology vol. 88, pp. 126-128 (Feb. 1981).

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