Process for producing valproic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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C07C 53128

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active

058565698

ABSTRACT:
A process for making valproic acid from an alkyl alkanoylacetate is disclosed. The alkyl alkanoylacetate is reacted with an n-propyl halide in a biphasic system in the presence of a base and a phase transfer catalyst. The product mixture is acidified to convert the resulting valproate salt into valproic acid.

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patent: 5101070 (1992-03-01), Yamamoto et al.
patent: 5344975 (1994-09-01), Zeiler
patent: 5672746 (1997-09-01), Nau et al.
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1990:590753, Zydzil et al. PL 136499 B1, Nov. 30, 1987, abstract, 1990.

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