Maytansinoids, pharmaceutical compositions thereof and method of

Details Maytansinoids, pharmaceutical compositions thereof and method of Maytansinoids, pharmaceutical compositions thereof and method of

1980-07-23

1981-04-28

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, A61K 31395, C07D49818

Patent

active

042645964

ABSTRACT:
Novel maytansinoid compounds of the formula: ##STR1## wherein X is H or Cl, R.sup.1 is an alkyl group of 2 to 4 carbon atoms and R.sup.2 is a lower alkyl group or an unsubstituted or substituted phenyl or aralkyl group, have antimitotic, antitumor and antimicrobial activities.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4162940 (1969-07-01), Higashide et al.
patent: 4190580 (1980-02-01), Hashimoto et al.
Higashide et al., "Nature", vol. 270, 22/29, Dec. 1977, pp. 721-722.
Kupchan et al., "Journal of Medicinal Chemistry", 1978, vol. 21, No. 1, pp. 31-37.

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