Sulfonamide-substituted compounds, processes for their preparati

Details Sulfonamide-substituted compounds, processes for their preparati Sulfonamide-substituted compounds, processes for their preparati

1997-12-15

1999-01-05

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546159, A61K 3147, C07D21542

Patent

active

058563385

ABSTRACT:
Compounds of formula I ##STR1## having the meanings indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias; for the treatment of ulcers of the gastrointestinal region; or for the treatment of diarrheal illnesses.

REFERENCES:
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patent: 5082858 (1992-01-01), Garcia et al.
patent: 5151442 (1992-09-01), Garcia et al.
E. Lohrmann, et al. "A new class of inhibitors of cAMP-mediated Cl-secretion in rabbit colon, acting by the reduction of cAMP-activated K+ conductance", Pflugers Arch-Eur J Physiol, pp. 517-530 (1995).
R.M. Soll et al., "N-Sulfonamides of Benzopyran-Related Potassium Channel Openers: Conversion of Glyburide Insensitive Smooth Muscle Relaxants to Potent Smooth Muscle Contractors", Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 5, pp. 769-773, (1994).

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