Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1998-06-29
1999-12-14
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
4352982, 435394, 435403, C12M 302
Patent
active
060016426
ABSTRACT:
A bioreactor and cell culturing method using the bioreactor have been developed to enhance cell production and growth and decrease the shear forces on the cells and multicellular aggregates. The bioreactor contains a dome-shaped culture vessel having walls defining an interior volume, an apex, a bottom circular edge, and a axis of symmetry perpendicular to the bottom circular edge; and a gas-permeable membrane fluidtightly integrated with the bottom circular edge of the culture vessel. The bioreactor may further contain a rotating base fluidtightly integrated with the gas-permeable membrane, wherein the rotating base is fixed to rotate about the axis of symmetry of the dome-shaped culture vessel set on a substantially horizontal axis.
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Beisner William H.
Wyle Laboratories, Inc. Life Sciences
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