Human myosin heavy chain-like proteins

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435325, 4352523, 4353201, 536 231, C12P 2106, C12N 1500, C07H 1700

Patent

active

060015934

ABSTRACT:
The invention provides human myosin heavy chain-like proteins (MHCP) and polynucleotides which identify and encode MHCP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating disorders associated with expression of MHCP.

REFERENCES:
Martin, A.F. et al., "C-terminal Isoforms of the Myosin Heavy Chain and Smooth Muscle Function," Comp. Biochem. Physiol., 117B(1):3-11 (1997).
Nieznanski, K. and Sobieszek, A., "Telokin (kinase-related protein) modulates the oligomeric state of smooth-muscle myosin light-chain kinase and its interaction with myosin filaments," Biochem J., 322(1):65-71 (1997).
Sutherland, C., et al., "Phosphorylation of caldesmon by smooth-muscle casein kinase II," Journal of Muscle Research and Cell Motility, 15:440-456 (1994).
Li, H., et al., "Multiple Substrates for cGMP-Dependent Protein Kinase from Bovine Aortic Smooth Muscle; Purification of P132," J. Vas. Res., 33(2):99-110 (1996).
Wilson, R., et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans," Nature, 368:32-38 (1994) (GI 532467).
Nasmyth, K. and Jansen, R, "The cytoskeleton in mRNA localization and cell differentiation," Curr Opin Cell Biol., 9(3):396-400 (1997).
Abchee, A. and Marian, A.J, "Prognostic Significance of .beta.-Myosin Heavy Chain Mutations is Reflective of Their Hypertrophic Expressivity in Patients with Hypertrophic Cardiomyopathy," J. Investig. Med., 45(4):191-196 (1997).
Wakasaki, H., et al., "Targeted overexpression of protein kinase C .beta.2 isoform in myocardium causes cardiomyopathy," Proc. Natl. Acad. Sci. USA, 94(17):9320-9325 (1997).
Bierhoff, E., et al., "Morphological Analogies of Fetal Prostate Stroma and Stromal Nodules in BPH," The Prostate, 31(4):234-240 (1997).
Wilson, R., et al., (GI 532467), GenBank sequence Database (Accession U13643), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 532473).
Ho, G. and Chisholm R.L., "Substitution Mutations in the Myosin Essential Light Chain Lead to Reduced Actin-activated ATPase Activity Despite Stoichiometric Binding to the Heavy Chain," The Journal of Biological Chemistry, 272(7):4522-4527 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human myosin heavy chain-like proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human myosin heavy chain-like proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human myosin heavy chain-like proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-862097

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.