Mitochondrial adenylate kinase

Details Mitochondrial adenylate kinase Mitochondrial adenylate kinase

1997-03-31

1999-01-05

Lau, Kawai

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 6, 4353201, 4352523, 435325, 536 232, 536 2431, C12N 912, C12N 1563, C12Q 168, C07H 2104

Patent

active

058561609

ABSTRACT:
The present invention provides a human mitochondrial adenylate kinase (HMAK) and polynucleotides which encode HMAK. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMAK.

REFERENCES:
Database EMBL/GenBank EST-C/EST-D, Accession number AA193643, Hillier et al., submitted 1995, (g1783054).
Adams, M.D. et al. "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." Nature (1995), vol. 377, Suppl. 6547, pp. 3-174, submitted to database EMBL/GenBank EST-C/EST-D as accession numb.
Nakazawa, A. et al. "Gene structures of three vertebrate adenylate kinase isozymes" Progress in Clinical and Biological Research (1990), vol. 344, pp. 495-514.
Zeleznikar, R.J. et al., "Evidence for Compartmentalized Adenylate Kinase Catalysis Serving a High Energy Phosphoryl Transfer Function in Rat Skeletal Muscle", J. Biol. Chem., 270(13): 7311-7319 (1995).
Xu, G. et al., "Characterization of Human Adenylate Kinase 3 (AK3) cDNA and Mapping of the AK3 Pseudogene to an Intron of the NF1 Gene", Genomics, 13: 537-542 (1992).
Yamada, M. et al., "Cloning and Characteristics of cDNA for Mitochondrial GTP:ATP Phosphotransferase of Bovine Liver", J. Biol. Chem., 264: 19192-19199 (1989).
Shahjahan, M., (Direct Submission), GenBank Sequence Database (Accession 217576), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 217576) (1991).
Shahjahan, M., (Direct Submission), GenBank Sequence Database (Accession D10373 D90434), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 217571; GI 217572; GI 217573; GI 217574) (1991).
Xu, G., (Direct Submission), GenBank Sequence Database (Accession 28577), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 28577) (1991).
Xu, G., (Direct Submission), GenBank Sequence Database (Accession X60673 S41502), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 28576) (1991).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession AA007279), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1463313) (1995).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession H65871), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1024611). (1995).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession R70844), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 844361) (1995).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession R39487), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 796943) (1995).
Auffray, C., et al., "Homo sapiens partial cDNA sequence," EMEST EMBL Database entry HSBA7D052, Accession No. F01168, 07 Mar. 1995, XP002070699.
The Institute for Genomic Research: `Est 12881 Uterus tumor I Homo sapiens cDNA 5` end similar to adenylate kinase isozyme 3, mitochondrial, EMEST EMBL Database entry HSZZO5381, Accession No. AA300170, 18 Apr. 1997, XP002070700.
Tanabe, T., et al., "Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes," Journal of Biochemistry, 113:200-207 (1993) XP002070697.

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