Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-30
1999-01-05
Houtteman, Scott W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 235, 536 2431, C12Q 168
Patent
active
058560947
ABSTRACT:
Methylation of p16 DNA and a resultant decrease in p16 gene expression is associated with transcriptional block and is associated with a variety of neoplasms. A method for detecting a neoplasm in a subject by detecting methylation of 5'CpG islands in p16 DNA, or detecting p16 mRNA or polypeptide levels in a sample is also provided.
REFERENCES:
Herman, et al., Hypermethylation-associated Inactivation Indicates a Tumor Suppressor Role for p15.sup.INK4B1, Cancer Research, 56:722, 1996.
Herman, et al., Inactivation of the CDKN2/p16/MTS1 Gene is Frequently Associated with: Aberrant DNA Methylation in All Common Human Cancers, Cancer Research, 55:4525, Oct. 15, 1995.
Merlo, et al., A Novel p16.sup.INK4A Transcript, Cancer Research, 55:2995, Jul. 15, 1995.
Shapiro, et al., Multiple Mechanisms of p16.sup.INK4A Inactivation in Non-Small Cell Lung Cancer Cell Lines, Cancer Research, 55:6200, Dec. 15, 1995.
Liggett, et al., p16 expression is modulated by an alternative transcript (p16.beta.) in vitro and may be a mechanism of tumor suppressor gene regulation, Proceedings of the American Association for Cancer Research, vol. 37(#20), Mar. 1996.
Serrano et al., "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4", Nature, Dec. 16, 1993, vol. 366, pp. 704-707.
Cairns et al., Cancer Research 55:224-227, Jan. 1995.
Baylin Stephen B.
Sidransky David
Houtteman Scott W.
The Johns Hopkins University School of Medicine
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