Process for the preparation of 2-(4'-nitrophenyl)-propionic acid

Details Process for the preparation of 2-(4'-nitrophenyl)-propionic acid Process for the preparation of 2-(4'-nitrophenyl)-propionic acid

1979-04-20

1980-12-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5115

Patent

active

042425247

ABSTRACT:
The present invention concerns a process for the preparation of 2-(4'-nitrophenyl)-propionic acid of the formula (I): ##STR1## More particularly, this invention relates to a process for the preparation of 2-(4'-nitrophenyl)-propionic acid (I) starting from para-nitroethylbenzene (PNEB) by carboxylation in the presence of alkaline phenates (Na and K).
The 2-(4'-nitrophenyl)-propionic acid (I) thus obtained finds a useful application as an intermediate for the preparation of chemical products.
For instance, acid (I) may be hydrogenated catalytically until obtaining the corresponding amino-derivative which is then condensed with ortho-cyanobenzyl-bromides in order to give isoindoline (as described in Belgian Pat. No. 774985).

REFERENCES:
patent: 3557196 (1971-01-01), Bottaccio
patent: 3734955 (1973-05-01), Patmore
patent: 3976677 (1976-08-01), Bottaccio
Bielstein, Band IX, p. 526.
Bielstein, Band IX (I), p. 207.

Affiliated with

Also associated with

Rating

Process for the preparation of 2-(4'-nitrophenyl)-propionic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 2-(4'-nitrophenyl)-propionic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 2-(4'-nitrophenyl)-propionic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-8608