Method of production of antigen-specific glycosylation inhibitin

Details Method of production of antigen-specific glycosylation inhibitin Method of production of antigen-specific glycosylation inhibitin

1995-04-04

1998-09-15

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 435 703, C12P 2102, C12P 2104

Patent

active

058077146

ABSTRACT:
A method for the recombinant production and for the isolation of antigen-specific glycosylation inhibiting factor (AgGIF) is provided. Also disclosed is a method for modulating the immune responses in an antigen-specific manner utilizing a AgGIF, comprising soluble non-specific GIF-TCR.alpha. chains which bind to the antigen, and which suppress the immune response in an antigen-specific fashion.

REFERENCES:
Mikayama et al., Proc. Natl. Acad. Sci. 90: 10056-10060, Nov. 1993.
Kuchroo et al., Proc Natl. Acad. Sci. 88: 8700-8704, Oct. 1991.
Fairchild et al., J. of Immunology, 145: 2001-2009, Oct. 1990.
Collins et al., Faseb Journal, 6: A1140, May 1992.
Thomas et al., J. of Immunology, vol. 148: 729-737, Feb. 1992.

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