Method for the immunoanalysis of cholesterol epoxides

Details Method for the immunoanalysis of cholesterol epoxides Method for the immunoanalysis of cholesterol epoxides

1984-11-21

1987-01-27

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 11, 435 15, 436501, 436543, 436817, 436822, 436823, G01N 3353, G01N 33566, G01N 33531, C12Q 160

Patent

active

046394206

ABSTRACT:
An immunoassay is provided for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently bonded bridge to a carrier protein. To detect cholesterol epoxide in the sample, it is converted to the hapten adduct, then contacted with the selected antibody.

REFERENCES:
Harris et al, `Enzymes Immunoassays`, Methods in Cancer Research, vol. 20, ed. by H. Bush & L. C. Yeoman, 1982.
Sparer et al, Urology, vol. 20, No. 3, 1982, pp. 244-250.
O'Neil et al, J. of Immunology, vol. 116, No. 2, 1976, pp. 363-366.
Forest et al, Steroids, vol. 28, No. 6, 1976, pp. 815-827.

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