Method for the introduction of a methyl group into the 7 positio

Details Method for the introduction of a methyl group into the 7 positio Method for the introduction of a methyl group into the 7 positio

1979-10-17

1980-12-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 45, C07D22128, C07D48902

Patent

active

042425140

ABSTRACT:
Disclosed is a novel method for the introduction of a 7-methyl group into the morphinan nucleus to thereby provide precursors for the preparation of therapeutically useful 7-methyl-4,5.alpha.-epoxy morphinan and morphinan-6-one compounds. The method involves reacting thebaine, dihydrothebaine or the enol acetate of dihydrocodeinone with lithium dimethyl cuprate to form the corresponding 7-methyl-4,5.alpha.-epoxy cleaved product.

REFERENCES:
patent: 2178010 (1939-10-01), Small et al.
Bentley, "The Chemistry of the Morpholine Alkaloids", Oxford University Press, London, (1954), pp. 272-288.
Bentley et al., J. Chem. Soc., pp. 947-957, (1952).
Posner, "Conjugate Addition Reactions of Organocopper Reagents", Organic Reactions, vol. 19, pp. 1-113, (1972).

Affiliated with

Also associated with

Rating

Method for the introduction of a methyl group into the 7 positio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the introduction of a methyl group into the 7 positio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the introduction of a methyl group into the 7 positio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-8546