Process for prostaglandin E.sub.1 production, and novel delta 7-

Details Process for prostaglandin E.sub.1 production, and novel delta 7- Process for prostaglandin E.sub.1 production, and novel delta 7-

1988-01-21

1989-07-04

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

547422, 547466, 547478, 556441, 556442, 560 53, 560118, 560121, 562463, 562503, C07C17700

Patent

active

048452823

ABSTRACT:
The present invention provides an industrially very advantageous process for producing prostaglandins E.sub.1 with fewer steps and in higher yield. The process comprises reacting a 7-hydroxyprostaglandin E with a reactive derivative of an organic sulfonic acid in the presence of a basic compound to form the corresponding 7-organic sulfonyloxyprostaglandin E, treating the resulting 7-organic sulfonyloxyprostaglandin E, after or without isolation, in the presence of a basic compound to form a .DELTA..sup.7 -prostaglandin E, thereafter selectively reducing the carbon-carbon unsaturated bond existing on the .alpha.-chain. Some of the 7-hydroxyprostaglandins E and .DELTA..sup.7 -prostaglandins E used in the process are novel compounds.

REFERENCES:
patent: 3435053 (1969-03-01), Real
Fiereu et al, Reagents for Organic Synthesis p. 1183 (1969).
House, Modern Synthetic Reacton p. 173 (1972).
Suzuki et al, Tet Letters. 23 (39) 4057 (1982).

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