Diaryl substituted cyclopentane and cyclopentene derivatives

Details Diaryl substituted cyclopentane and cyclopentene derivatives Diaryl substituted cyclopentane and cyclopentene derivatives

1988-03-14

1989-07-04

Gray, Bruce

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514605, 514640, 514646, 514647, 514676, 514684, 514708, 514709, 514710, 514712, 514713, 514716, 514719, 564 79, 564 83, 564 95, 564 99, 564256, 564265, 564307, 564440, 564441, 564442, 564443, 568 29, 568 30, 568 31, 568 33, 568 36, 568 37, 568 43, 568 44, 568 49, 568 62, 568306, 568303, 568644, 568645, 568646, A61K 3118, C07C149273

Patent

active

048451290

ABSTRACT:
The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated broncho-constriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lug injury.

REFERENCES:
patent: 2864868 (1958-12-01), Bader
Allen et al., J. Am. Chem. Soc., vol. 77, No. 8, pp. 2315-2317, (1955).
Doyama et al., Chemical Abstracts, vol. 106, No. 175799b, (1987).
Khand et al., Chemical Abstracts, vol. 90, No. 86801e, (1979).

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