Organic compounds and their pharmaceutical use

Details Organic compounds and their pharmaceutical use Organic compounds and their pharmaceutical use

1986-12-04

1989-07-04

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548253, 558396, 558397, 558413, 558414, 562480, 562452, 564161, 564163, C07D25704, A61K 3141

Patent

active

048451100

ABSTRACT:
There are provided anti-allergic pharmaceutical compounds of formula: ##STR1## in which n is 0, 1 or 2; R.sup.1 is a hydrocarbyl group containing 6 to 30 carbon atoms and optionally substituted with an optionally substituted phenyl group; R.sup.2 is (i) optionally optionally protected tetrazolyl, --COR.sup.6 where R.sup.6 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, an optionally protected amino acid residue or --NR.sub.2.sup.7 where each R.sup.7 is hydrogen or C.sub.1-4 alkyl, and --NHR.sup.8 where R.sup.8 is hydrogen, a protecting group, an optionally protected amino acid residue, C.sub.1-4 alkyl or --COR.sup.9 where R.sup.9 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy, or (iii) C.sub.1-10 alkyl substituted with a group selected from ##STR2## where each R.sup.10 is hydrogen or C.sub.1-4 alkyl; and R.sup.3, R.sup.4 and R.sup.5 are each selected from hydrogen, carboxyl, C.sub.2-5 alkoxycarbonyl, C.sub.1-4 alkyl, hydroxyl, optionally protected tetrazolyl, halo, trifluoromethyl, nitrile, nitro and --CONR.sub.2.sup.11 where each R.sup.11 is hydrogen or C.sub.1-4 alkyl; and salts thereof.

REFERENCES:
Bohlmann et al., Chem. Ber., 98(9), 3015 (1965).
Jonczyk et al., J. Org. Chem., 48, 910 (1983).
Knochel et al., Tetrahedron Letters, 26, 425 (1985).
Labidalle et al., Ann. Pharm. Fr., 39 (6), 545 (1981).
Van Tamelen et al., J. Am. Chem. Soc., 103 (15), 4615 (1981).

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