Certain pyridyl derivatives useful as leukotriene antagonists

Details Certain pyridyl derivatives useful as leukotriene antagonists Certain pyridyl derivatives useful as leukotriene antagonists

1987-02-17

1989-07-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514348, 514350, 514354, 514356, 546294, 546295, 546296, 546298, 546301, 546302, C07D21355, A61K 3144

Patent

active

048451088

ABSTRACT:
Compounds having the formula: ##STR1## are antagonists of leukotrines of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.

REFERENCES:
patent: 4193995 (1980-03-01), Wasson et al.
patent: 4219477 (1980-08-01), Fujimoto et al.
patent: 4666928 (1987-02-01), Young et al.
DeJohn et al., J. Heterocyclic Chem., 20; 1295-1302, 1983.

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