Disubstituted acetylenes bearing heteroaromatic and heterobicycl

Details Disubstituted acetylenes bearing heteroaromatic and heterobicycl Disubstituted acetylenes bearing heteroaromatic and heterobicycl

1993-03-08

1995-01-10

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549398, 549407, 514444, 514456, 514863, C07D31174, A61K 3135, A61K 3138, A61K 3134

Patent

active

053808770

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-2; and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

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