Process for the production of 7-acylindoles

Details Process for the production of 7-acylindoles Process for the production of 7-acylindoles

1993-06-30

1995-01-10

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548510, 548490, 548466, C07D40106

Patent

active

053808576

ABSTRACT:
A process for the production of 7-acylindoles of the general formula: ##STR1## starting from indoline of the formula: ##STR2## Indoline is cyanized in a first stage to 7-cyanoindoline of the formula: ##STR3## The latter is catalytically dehydrogenated in a second stage to 7-cyanindole of the formula: ##STR4## The latter is then acylated in a third stage with an organometallic compound of the formula:

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Bakke, CA 72:121360n, 1970.
Wagner & Zook, John Wiley & Sons, Inc., p. 332, 1956.
Walsh et al., J. Med. Chem., vol. 27, No. 11, (1984), pp. 1379 to 1388.

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