Process for resolving chiral intermediates used in making calciu

Details Process for resolving chiral intermediates used in making calciu Process for resolving chiral intermediates used in making calciu

1989-11-20

1990-10-16

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

510 17, 562431, C07D28110

Patent

active

049636715

ABSTRACT:
This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y.sup.1 and Y.sup.2 are each independently lower alkyl and R.sup.1 is hydrogen or lower alkyl. The compound is treated with a chiral acid (tartaric aicd preferred) in an organic solvent (ethanol preferred) to yield the (+)-threo enantiomer, which is then recovered from the reaction mixture. This enantiomer may then be used to produce the preferred (+)-cis enantiomer of certain benzothiazepine cardiovascular agents.

REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
Kugita et al., "Synthesis of 1,5-Benzothiazepine Derivatives", I Chem. Pharm. Bull. vol. 19 pp. 2028 to 2037 (1970).

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