Antibodies for GM-CSF receptor and uses thereof

Details Antibodies for GM-CSF receptor and uses thereof Antibodies for GM-CSF receptor and uses thereof

1995-01-25

1999-08-03

Spiegel, Carol A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303887, 5303896, 435 724, 435721, 436548, C07K 1600

Patent

active

059327049

ABSTRACT:
Antibodies capable of binding to the a subunit of the human GM-CSF receptor are described. These antibodies can inhibit the proliferation of cells whose growth is dependent upon the presence of human GM-CSF. Methods of assaying for the human GM-CSF receptor are also disclosed.

REFERENCES:
patent: 5629283 (1997-05-01), Nicola et al.
Chiba, S. et al. Journal Biological Chemistry,265, No. 32:19777-19781 (Nov. 15, 1990).
Watanabe, W., et al., Blood 80, No. 9:2215-2220 (Nov. 1, 1992).
Sasaki, K., et al., Biochem. Biophys. Res. Commun. 183, No. 1:252-275 (Feb. 28, 1992).
Nicola, N.A., et al., Blood, 82, No. 6:1724-1731 (Sep. 15, 1993).
Harlow et al, 1988. Antibodies. A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, pp. 72-74.
Gearing et al, 1989. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor, EMBO J 8:3667-76.
Raines et al, 1991 (Sep.). Identification and moleular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor PNAS 88:8203-7.
Maurer et al, 1980. Proteins and polypeptide as antigens. Meth. Enzymol. 70:49-70.
Goding, 1983. Monoclonal Antibodies: Principles and Practice. Academic Press, Inc., Orlando. pp. 1-3, 40.

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