Protein inhibiting the growth of human endometrial fibroblasts

Details Protein inhibiting the growth of human endometrial fibroblasts Protein inhibiting the growth of human endometrial fibroblasts

1997-08-29

1999-08-03

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530327, 530399, 530850, 435 703, 435 704, 435948, 436 64, 436517, C07K 1700, C12P 2104, G01N 3348

Patent

active

059327006

ABSTRACT:
A novel cell growth-inhibiting protein is provided. The cell growth-inhibiting protein, obtainable from extract of human uterine endometrial carcinoma, has the amino acid sequence rich in hydrophobic residue at its N-terminal, has a molecular weight of about 68,000 dalton, and is considered to act as a paracrine growth-inhibiting factor in an organism.

REFERENCES:
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Bowie et al, Science, Vol. 297, pp. 1306-1310, Mar. 16, 1990.
Houghten et al, Vaccines 86, pp. 21-25, Cold Spring Harbor Laboratories, 1986.
Matsunami et al, Research Communications in Chemical Pathology and Pharmacology, vol. 73, No. 3, pp. 371-374, 1991.
Furui et al, Curr. Chem. Pract. Ser. vol. 65, pp. 235-239, 1993.
Furui et al, Cancervol. 73, No. 4, pp. 1239-1244, Feb. 15, 1994.
Proceedings of the Society for Experimental Biology & Medicine vol. 203, No. 1 May 1993 pp. 117-122 Imai et al "Prolactin Binds to Human Endometrial Fibroblasts and Inhibits Mitogenicity etc." (1993).
Cancer vol. 73, No. 4, Feb. 15, 1994 pp. 1239-1244 Furui et al "A Putative New Proteinous Factor Negative for Stromal Growth" (1994).

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