Methods and compositions for the production of haemophilus influ

Details Methods and compositions for the production of haemophilus influ Methods and compositions for the production of haemophilus influ

1992-02-11

1995-01-10

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352523, 4353201, 536 237, 4242561, C12N 121, C12N 1531

Patent

active

053806557

ABSTRACT:
Disclosed are DNA and other biological compositions, including biological cultures, for preparing Haemophilus influenzae antigens by recombinant means. The disclosed recombinant antigens are suitable for use in the preparation of immunogenic compositions for use in vaccination against various Haemophilus influenzae type B infections. Particular embodiments disclosed include DNA segments which encode the P2 major outer membrane protein antigen, also referred to as the 39/38 protein, biological cultures transformed by these DNA segments, and the preparation of recombinant P2 antigen through the use of these biological cultures.

REFERENCES:
patent: 4554101 (1985-11-01), Hopp
Gulig, P. A. et al. 1983. Infect. Immun. vol. 42 pp. 516-524
Benjamin, R. C., et al. 1984, Gene vol. 31 pp. 173-185.
Bulawa, C. E., et al. 1986. Cell vol. 46 pp. 213-225.
Mason, P. J., et al. 1985. "Hybridisation in the Analysis of Recombinant DNA" In Nucleic Acid Hybridisation, Ed. B. D. Hames et al., IRL Press, Oxford. pp. 113-137.
Munson, R. S., et al. 1983. J. Clin. Invest. vol. 72 pp. 677-684.
Watson, M. E. E. 1984. Nucleic Acis Research vol. 12 pp. 5145-5164.
EPO Search Report for EPC Application 88311691.5.
Danner et al. (1982), Gene, 18:101-105.
Thomas et al. (1986), Infect. Immun., 52:812-817.
Loeb, M. R. (1987), Infect. Immun., 55:2612-2618.
Green et al. (1987), Infect. Immun., 55:2878-2883.
Gonzales et al. (1987), Abst. Ann. Meet. Am. Soc. Microbiol., 87:79.
Gonzales et al. (1987), Infect Immun., 55:2993-3000.
Hansen et al. (1988), Abs. Ann. Meet.,-1988, Abs. No. D-172, p. 99.
Munson, R. S. (1988), Abs. Ann. Meet.,-1988, Abs. No. D-201, p. 104.
Munson et al. (1988), Abs. 1988 ICAAC, Abs. No. 1124, p. 308.
Munson et al. (1988), Abs. 1988 ICAAC, Abs. No. 1125, p. 308.
Munson et al. (1988), Infect. Immun., 56:2235-2242.
Hansen et al. (1988), Infect. Immun., 56:2709-2716.
Munson et al. (1989), Infect. Immun., 57:88-94.
Hansen et al. (1989), Infect. Immun., 57:1100-1107.

Affiliated with

Also associated with

Rating

Methods and compositions for the production of haemophilus influ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for the production of haemophilus influ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the production of haemophilus influ will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-850218