Stable growth hormone releasing factor preparation

Details Stable growth hormone releasing factor preparation Stable growth hormone releasing factor preparation

1988-03-08

1990-10-16

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514561, 514970, 530324, A61K 3736

Patent

active

049635298

ABSTRACT:
Growth hormone releasing factor (GRF) preparation which is excellent in stablity by having human serum albumin or glycine incorporated therein, with or without buffer. An amount of human serum albumin or glycine contained is usually 100 .mu.g to 30 mg per 100 .mu.g GRF. The preparation may be in the solid or solution form, preferably in the lyophilized form. An amount of buffer, if added, is preferably enough so that pH of the preparation is kept at 2-7. More preference is that the preparation is kept in nitrogen gas atmosphere. The lyophilized preparation is readily usable for, for example, injection.

REFERENCES:
patent: 3803309 (1974-04-01), Desaulles
patent: 4452775 (1984-06-01), Kent
patent: 4460576 (1984-07-01), Kawauchi
patent: 4563352 (1986-01-01), Rivier et al.
patent: 4622312 (1986-11-01), Felix et al.
Ling et al., PNAS USA, vol. 81 (1984), pp. 4302-4306.
Seifert et al., Nature, vol. 313 (1985), pp. 487-489.

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