Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-04
1999-08-03
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514307, 546139, 546141, 546148, C07D21720, A61K 3147
Patent
active
059325909
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Ciccarone Terrence M.
deSolms S. Jane
Daniel Mark R.
Davis Zinna Northington
Merck & Co. , Inc.
Muthard David A.
Pecoraro Dianne
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