Triazine compounds and methods of use therefor

Details Triazine compounds and methods of use therefor Triazine compounds and methods of use therefor

1997-03-27

1999-08-03

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544182, A61K 3153, C07D253075, C07D40904

Patent

active

059325780

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a substituted 1,2,4-triazine of the formula (I) ##STR1## and the biologically and pharmaceutically acceptable salts thereof; capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 3961936 (1976-06-01), Westphal et al.
patent: 4036632 (1977-07-01), Westphal et al.
patent: 4057417 (1977-11-01), Dickore et al.
patent: 4386953 (1983-06-01), Kranz et al.
patent: 4470842 (1984-09-01), Kranz et al.
patent: 4547216 (1985-10-01), Bohner
patent: 4632694 (1986-12-01), Tocker
patent: 4758583 (1988-07-01), Cerami et al.
patent: 5076833 (1991-12-01), Krantz et al.
Brownlee, "The Pathological implications of Protein Glycation," Clin. Invest. Med., vol. 18, No. 4, pp. 275-281, 1995.
Brownlee, "Advanced Protein Glycosylation in Diabetes and Aging," Annu. Rev. Med., vol. 46, pp. 223-234, 1995.
Vlassara et al., "Biology of Disease," Laboratory Investigation, vol. 70, No. 2, pp. 138-151, 1994.
Eia et al., "Synthesis and Condensation reactions of Some 6-Substitutedbenzyl-3-Hydrazino-2,5-Dihydro-1,2,4-Triazin-5-Ones," Egypt. J. Pharm. Sci., vol. 31, No. 1-4, pp. 337-342, 1990.
Striker et al., "Administration of AGEs in vivo Induces Extracellular Matrix Gene Expression," Nephrol. Dial. Transplant, vol. 11, Suppl. 5, MEDLINE abstract provided, pp. 62-65, 1996.
Daunis et al., "Effect of the substituent at position 6 of 3-hydrazino-5-hydroxytriazines on the Cyclization into s-triazolo-as-triazine", Bull. Soc. Chim., vol. 3-4 Part 2, pp. 857-863, 1975.
Molina et al., "Iminophosphorane-mediated Synthese of vol. 12, pp. 2037-2049, 1986.
Basnak et al. (1975) Collect. Czech. Commun. 40:1038-42.
Bierowska-Charytonowicz et al.(1976)Arch. Immun. Ther. Exp. 24:883-99.
Bierowska-Charytonowicz et al.(1973) Rocz. Chem. 47(11):2199-201.
Brownlee et al., Science, 232, pp. 1629-1632 (1986).
Brownlee et al., Diabetes, 35, Suppl. 1, p. 42A (1986).
Essassi et al. (1977) Tetrahedron 33(21):2807-12.
Lachowicz et al. (1974) Act. Microbiol. Pol., Ser. A. 6(2):147-54.
Lavergne et al. (1975) J. Heterocycl. Chem. 12(6):1095-101.
Molina et al. (1989) Heterocycles 29(8):1607-13.
Ueda et al. (1964) Chem. Pharm. Bull. 12:100-3.

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