Cardiac diseases improving agents

Details Cardiac diseases improving agents Cardiac diseases improving agents

Filed on

1997-12-16

Date issued

1999-08-03

Examiner

Ramsuer, Robert W.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

514210, 5142395, 514255, 514330, 514352, 514381, 514423, 514533, 514534, 514535, 514567, A61K 3144, A61K 31445, A61K 31535

Type

Patent

Status

active

Patent number

059325755

Description

ABSTRACT:
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly, this invention relates to cardiac diseases improving agents composed of effective ingredients of aromatic compounds or pharmacologically acceptable salts thereof shown by below mentioned general formula. ##STR1## (wherein, substituents thereof typically include, R.sup.1, R.sup.4, R.sup.13 representing hydrogen atom, an alkyl group, a haloalkyl group and so forth, R.sup.8 representing --CO--, --SO.sub.2 -- or single bond, R.sup.2 representing a 3-7 membered aliphatic cyclic amino group having at least one nitrogen atom, R.sup.7 representing --CO-- or --SO.sub.2 --, and R.sup.12 representing N-substituted valeramido group.)

REFERENCES:
patent: 5128355 (1992-07-01), Carini et al.
patent: 5153197 (1992-10-01), Carini et al.
patent: 5155118 (1992-10-01), Carini et al.
patent: 5696118 (1997-12-01), Yanaka et al.
patent: 5731310 (1998-03-01), Yanaka et al.
patent: 5739131 (1998-04-01), Yanaka et al.
D.M. Pollock et al., "Angiotensin II Receptor Blockade Improves Renal Function in Rats with Reduced Renal Mass" J. Pharm. and Experimental Therapeutics 267(2):657-663 (1993).

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