Process for the preparation of cis, endo-2-azabicyclo-[3.3.0]-oc

Details Process for the preparation of cis, endo-2-azabicyclo-[3.3.0]-oc Process for the preparation of cis, endo-2-azabicyclo-[3.3.0]-oc

1988-11-02

1989-11-07

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 22, 560 39, 560 41, 560121, 560125, 560169, 560170, 562437, 562443, 562444, 562448, 562449, 562503, 562508, 562565, 562567, 549436, 548493, C07C10110

Patent

active

048794031

ABSTRACT:
Compounds of the formula I ##STR1## in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R.sup.1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring .alpha.-aminoacid, which may be protected, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.

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Houben Weyl, Methoden Der Organischen Chemie, VIII, 533 (1952).
W. Koenig and R. Geiger, "Racemisierung Bei Peptidsynthesen", Chemische Berichte, 103, 2024-2033 (1970).
Chem. Abstr. 69, 35847h (1968).
Chem. Abstr. 88, 37442p (1978).
Chem. Abstr. 89, 129529w (1978).
Chem. Abstr. 89, 215732p (1978), (Agbalyan et al.).
Tetrahedron Letters (1968) 1317-1319.

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