Liposomal human calcitonin gene-related peptide composition and

Details Liposomal human calcitonin gene-related peptide composition and Liposomal human calcitonin gene-related peptide composition and

1997-11-26

1999-08-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424460, 514929, A61K 9127

Patent

active

059322446

ABSTRACT:
The present invention provides a pharmaceutical composition of hCGRP and the preparation of the same. The composition comprises liposomes from nature soybean phospholipid, in which the weight ratio of hCGRP to soybean phospholipid is 1-2 to 100-8000. The half-life of the composition is longer than 72 hours, and the stability of the composition is also enlongated. The composition can be administrated intravenous infusion, oral, nasal mucosal spray in an amount of 0.1-10 pg hCGRP per kg body weigh to treat hypertension and congestive heart failure of a human. The bioavailability of approximately 80%.

REFERENCES:
patent: 4515736 (1985-05-01), Deamer
patent: 5374618 (1994-12-01), Craig et al.
patent: 5631394 (1997-05-01), Wei et al.
patent: 5693622 (1997-12-01), Wolff et al.

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