Solid phase peptide synthesis

Details Solid phase peptide synthesis Solid phase peptide synthesis

1988-06-20

1989-11-07

Schrin, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530325, C07K 104, C07K 106

Patent

active

048793710

ABSTRACT:
A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stalbe to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.

REFERENCES:
patent: 3995094 (1976-11-01), Grasby et al.
patent: 4507230 (1985-03-01), Tam et al.
patent: 4623484 (1986-11-01), Carpino et al.
patent: 4680339 (1987-07-01), Fong
patent: 4764594 (1988-08-01), German et al.
patent: 4764595 (1988-08-01), German et al.
patent: 4801665 (1989-01-01), German et al.
Samanen et al., "The p-Methylsulfinylbenzyl Groups, A Selectively Clearable Carboxy Protecting Group", 9th American Peptide Symposium in Toronto, pp. 225-228, Jun. 23-28, 1985.

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